Best way to play Axs from BTN/CO vs single raise open (live)

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Best way to play Axs from BTN/CO vs single raise open (live)

What would be some pros and cons to either flat or 3bet Axs from BTN/CO against single raise from early and middle, in live games, around 200bb deep?

Against Raise + Call + Call.. is it better to flat and take a flop against multiple players with a higher SPR or isolating and plaing HU brings us a higher EV?

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