I am studying my game with simplepoker and want to create an exploitiv gameplan.
Lets say I want to compaire 3 different strategies on the turn:
1. Smallbetonly
2. Overbetonly
3. Mixedbetsizes
Obviously the first 2 strategies are much easier to play than a mixedstrategy. In most cases a mixedstrategy has the highest Ev. At which point should we start mixing it up? Is a difference of 4-5bb/100hands significant enough or could we just ignore them for simplification?

I personaly took 5bb/100 as significant, but its more or less guessing..