Popodopolos

In the episode he talks about how defending in the bb against a 2.25bb raise from late position. I’m currently playing 5NL and no one raises 2.25bb it’s almost always 3bb minimum, sometimes more. Is it still worth defending against 3bb open with a wider range like the Q4s and the 87o he mentions as your pot odds won’t be as good or should you tighten your range a little?