Correct me if I'm wrong, but I believe the reason Piosolver prefers mixed strategies is because they allow you to capitalize on your range advantage, regardless of the specific hands you hold.
For example, if you're the PFR and the flop is A-K-Q, you should bet with a high frequency regardless of what cards you hold, because you have a range advantage and Villain should be more likely to fold.
However, doesn't this assume that Villain understands the importance of ranges and will give you "credit" for a strong hand when the board is favorable to your range? If Villain isn't thinking in terms of ranges, does it therefore make sense to forget about mixed strategies, and bet more polarized (strong hands for value and weak hands as bluffs)?
I've been having a lot of fun playing with Piosolver the last few days... But I'm still trying to figure out the best way to study Pio vs weak and exploitable opponents. Anyone have any tips for that?