When in the micros should you just play like a NIT as most people are just opening and calling with whatever two cards?

If the above is true/semi true to the fact that you have to vastly differ from normal poker strategy when playing in the micros, doesnt this end up hurting you in the long run?

Should I learn to play good poker or learn to beat the micros? Or is my thinking flawed, and good poker will end up crushing the micros in the long run, and there's just more variance?

Thanks.