What are the main general population exploits?

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What are the main general population exploits?

I've been playing around with Piosolver, and have been analyzing optimal strategies vs some of the most common errors average low-stakes players make, like

a) Too loose pre-flop range; b) low bluff frequency; c) high call frequency

For example, I've been analyzing a tight OOP range vs loose IP range on various flop textures, and have been node locking so that the IP player has 0% bluff raising frequency, and calls all pairs, all draws, and all Ace high cards.

Given these exploits, Pio wants us to bet virtually every flop texture 100% of the time with a large bet size.

Basically, the strategy is to bet the flop 100% of the time, because we have such a big range advantage (the only exceptions are underpairs that have strong SDV and are invulnerable, like checking Pocket Queens on a King-high flop).

The turn betting frequency is still very high, but slightly lower... Since Villain is likely to have a pair, we should bet complete air less frequently, but still lots of betting.

I'm wondering... Does this basic strategy work in live games vs weak players? In other words, heads up against against fish with weak ranges... Should we pretty much be c-betting every flop, and barreling with most of our range on the turn?

To what extent do these strategies actually work in live games, and what other exploits should I be considering as I continue to work with Pio?

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